If you had to reinstall Windows Mobile Device center on a Windows 10 pc after an update or system restore and WMDC will not install or run, you may have a required software service not running or enabled.
Follow these steps to try and correct.
1. Go to Windows start menu, then search for Services app.
2. Make sure the Windows Mobile-2003-based device connectivity is enabled and running.
If it is not running, double click on it and configure it to run:
Close services after it is running.
Then try and run or install WMDC again.